2018 schedule American Broadcasting Company September 1, 2018 and December 1, 2018
| Date | Away | Home | Notes |
|---|---|---|---|
| September 1 | #1 Alabama 51 | Louisville 14 | Camping World Kickoff |
| September 8 | #13 Penn State 51 | Pittsburgh 6 | |
| September 15 | #4 Ohio State 40 | #15 TCU 28 | Game played at AT&T Stadium |
| September 22 | #7 Stanford 38 | #20 Oregon 31 (OT) | |
| September 29 | #4 Ohio State 27 | #9 Penn State 26 | |
| October 6 | #6 Notre Dame 45 | #24 Virginia Tech 23 | |
| October 13 | #15 Wisconsin 13 | #12 Michigan 38 | |
| October 20 | #2 Ohio State 20 | Purdue 49 | |
| October 27 | #6 Texas 35 | Oklahoma State 38 | |
| November 3 | #7 Oklahoma 51 | Texas Tech 46 | |
| November 10 | #2 Clemson 27 | #17 Boston College 7 | |
| November 17 | #19 Cincinnati 13 | #11 UCF 38 | |
| November 24 | #3 Notre Dame 24 | USC 17 | |
| December 1 | #2 Clemson 42 | Pittsburgh 10 | 2018 ACC Championship Game |
