2016 schedule American Broadcasting Company September 3, 2016 and December 3, 2016[]
| Date | Away | Home | Notes |
|---|---|---|---|
| September 3 | #20 USC 6 | #1 Alabama 52 | Advocare Classic |
| September 10 | Virginia Tech 24 | #17 Tennessee 45 | Battle at Bristol |
| September 17 | USC 10 | #7 Stanford 27 | |
| September 24 | #7 Stanford 22 | UCLA 13 | |
| October 1 | #3 Louisville 36 | #5 Clemson 42 | |
| October 8 | #23 Florida State 20 | #10 Miami 19 | |
| October 15 | #2 Ohio State 30 | #8 Wisconsin 23 (OT) | |
| October 22 | #2 Ohio State 21 | Penn State 24 | |
| October 29 | #3 Clemson 37 | #12 Florida State 34 | |
| November 5 | #9 Nebraska 3 | #6 Ohio State 62 | |
| November 12 | #3 Michigan 13 | Iowa 14 | |
| November 19 | #8 Oklahoma 56 | #10 West Virginia 28 | |
| November 26 | #13 Florida 13 | #15 Florida State 31 | |
| December 3 | #3 Clemson 42 | #19 Virginia Tech 35 | 2016 ACC Championship Game |