2010 schedule American Broadcasting Company September 4, 2010 and December 4, 2010
ABC did not air games on either September 11 or October 16 due to broadcasts of NASCAR Sprint Cup Series races.
| Date | Away | Home | Notes |
|---|---|---|---|
| September 4 | #21 LSU 30 | #18 North Carolina 24 | Chick-fil-A Kickoff Game (Georgia Dome, Atlanta) |
| September 18 | #6 Texas 24 | Texas Tech 14 | Split-national (54% of the United States, with SD reverse mirror on ESPN2) |
| Notre Dame 31 | Michigan State 34 (OT) | Split-national (46% of the United States, with reverse mirror on ESPN2) | |
| September 25 | #24 Oregon State 24 | #3 Boise State 37 | |
| October 2 | #9 Stanford 31 | #4 Oregon 52 | Split-national (53% of the United States, with SD reverse mirror on ESPN2) |
| Notre Dame 31 | Boston College 13 | Split-national (47% of the United States) | |
| October 9 | #23 Florida State 45 | #13 Miami (Fla.) 17 | Split-national (79% of the United States) |
| USC 35 | #16 Stanford 37 | Split-national (21% of the United States) | |
| October 23 | #3 Oklahoma 27 | #18 Missouri 36 | |
| October 30 | #1 Oregon 53 | #24 USC 32 | Split-national (79% of the United States) |
| #10 Ohio State 52 | Minnesota 10 | Split-national (21% of the United States) | |
| November 6 | #13 Arizona 17 | #10 Stanford 42 | Split-national (82% of the United States) |
| #14 Missouri 17 | Texas Tech 24 | Split-national (18% of the United States) | |
| November 13 | #12 Oklahoma State 33 | Texas 16 | Split-national (61% of the United States) |
| Clemson 13 | Florida State 16 | Split-national (20% of the United States) | |
| USC 24 | #18 Arizona 21 | Split-national (19% of the United States) | |
| November 20 | #9 Nebraska 6 | #18 Texas A&M 9 | Split-national (53% of the United States) |
| Florida State 30 | Maryland 16 | Split-national (28% of the United States) | |
| #20 USC 7 | Oregon State 36 | Split-national (19% of the United States) | |
| November 27 | #14 Oklahoma 47 | #10 Oklahoma State 41 | Split-national (54% of the United States) |
| Notre Dame 20 | USC 16 | Split-national (46% of the United States) | |
| December 4 | #10 Oklahoma 23 | #13 Nebraska 20 | Big 12 Championship Game (Cowboys Stadium, Arlington, Texas) |
