2010 schedule American Broadcasting Company September 4, 2010 and December 4, 2010[]
ABC did not air games on either September 11 or October 16 due to broadcasts of NASCAR Sprint Cup Series races.
| Date | Away | Home | Notes |
|---|---|---|---|
| September 4 | #21 LSU 30 | #18 North Carolina 24 | Chick-fil-A Kickoff Game (Georgia Dome, Atlanta) |
| September 18 | #6 Texas 24 | Texas Tech 14 | Split-national (54% of the United States, with SD reverse mirror on ESPN2) |
| Notre Dame 31 | Michigan State 34 (OT) | Split-national (46% of the United States, with reverse mirror on ESPN2) | |
| September 25 | #24 Oregon State 24 | #3 Boise State 37 | |
| October 2 | #9 Stanford 31 | #4 Oregon 52 | Split-national (53% of the United States, with SD reverse mirror on ESPN2) |
| Notre Dame 31 | Boston College 13 | Split-national (47% of the United States) | |
| October 9 | #23 Florida State 45 | #13 Miami (Fla.) 17 | Split-national (79% of the United States) |
| USC 35 | #16 Stanford 37 | Split-national (21% of the United States) | |
| October 23 | #3 Oklahoma 27 | #18 Missouri 36 | |
| October 30 | #1 Oregon 53 | #24 USC 32 | Split-national (79% of the United States) |
| #10 Ohio State 52 | Minnesota 10 | Split-national (21% of the United States) | |
| November 6 | #13 Arizona 17 | #10 Stanford 42 | Split-national (82% of the United States) |
| #14 Missouri 17 | Texas Tech 24 | Split-national (18% of the United States) | |
| November 13 | #12 Oklahoma State 33 | Texas 16 | Split-national (61% of the United States) |
| Clemson 13 | Florida State 16 | Split-national (20% of the United States) | |
| USC 24 | #18 Arizona 21 | Split-national (19% of the United States) | |
| November 20 | #9 Nebraska 6 | #18 Texas A&M 9 | Split-national (53% of the United States) |
| Florida State 30 | Maryland 16 | Split-national (28% of the United States) | |
| #20 USC 7 | Oregon State 36 | Split-national (19% of the United States) | |
| November 27 | #14 Oklahoma 47 | #10 Oklahoma State 41 | Split-national (54% of the United States) |
| Notre Dame 20 | USC 16 | Split-national (46% of the United States) | |
| December 4 | #10 Oklahoma 23 | #13 Nebraska 20 | Big 12 Championship Game (Cowboys Stadium, Arlington, Texas) |