2008 schedule American Broadcasting Company August 30, 2008 and December 6, 2008[]
ABC did not air games on either September 6 or October 11 due to broadcasts of NASCAR Sprint Cup Series races.
| Date | Away | Home | Notes |
|---|---|---|---|
| August 30 | #24 Alabama 34 | #9 Clemson 10 | Chick-fil-A Kickoff Game (Georgia Dome, Atlanta)
Split-national (71% of the United States) |
| Michigan State 31 | California 38 | Split-national (29% of the United States) | |
| September 13 | #5 Ohio State 3 | #1 USC 35 | |
| September 20 | #3 Georgia 27 | Arizona State 10 | |
| September 27 | #22 Illinois 24 | #12 Penn State 38 | Split-national (70% of the United States) |
| Virginia Tech 35 | Nebraska 30 | Split-national (30% of the United States) | |
| October 4 | #14 Ohio State 20 | #18 Wisconsin 17 | Split-national (63% of the United States) |
| #23 Oregon 10 | #9 USC 44 | Split-national (37% of the United States) | |
| October 18 | #11 Missouri 31 | #1 Texas 56 | |
| October 25 | #3 Penn State 13 | #10 Ohio State 6 | |
| November 1 | #1 Texas 33 | #6 Texas Tech 39 | |
| November 8 | #8 Oklahoma State 20 | #2 Texas Tech 56 | Split-national (82% of the United States) |
| #21 California 3 | #7 USC 17 | Split-national (18% of the United States) | |
| November 15 | Boston College 27 | #20 Florida State 17 | Split-national (80% of the United States) |
| #11 Oklahoma State 30 | Colorado 17 | Split-national (20% of the United States) | |
| November 22 | #2 Texas Tech 21 | #5 Oklahoma 65 | |
| November 29 | #3 Oklahoma 61 | #11 Oklahoma State 41 | |
| December 6 | #19 Missouri 21 | #4 Oklahoma 62 | Big 12 Championship Game (Arrowhead Stadium, Kansas City) |